Yu Jie

Yu Jie

Associate Researcher · Master's Supervisor Institute of Basic Research in Clinical Medicine & Immunology, Zhejiang Chinese Medical University National Key Discipline / Zhejiang Provincial Key Laboratory

Profile: Postdoctoral fellow in the Department of Pharmacology, University of Arizona. PhD from the College of Pharmaceutical Sciences, Zhejiang University (2015), Zhejiang University Institute of Neuroscience. Selected for the first cohort of the Zhejiang Provincial Higher-Education Leading Talent Training Program (Project 5246) as "High-Level Distinguished Talent"; committee member of the Pharmaceutical and Rehabilitation Professional Committee, Chinese Association of Rehabilitation Medicine; vice chair of the Youth Committee of Immunology, Zhejiang Association of Integrative Medicine; awardee of the ZCMU Project 5151 talent program ("Yuanzhi Youqing"). Peer reviewer for Chem Biol Interact, Neurochem Int, and other journals.

Research: Pathogenesis and neuropharmacology of neuroimmune system disorders such as chronic pain and rheumatoid arthritis, and pharmacological research on Chinese medicine for rheumatic immune diseases. This includes CRMP2-related proteins regulating neuroimmune cells and related pathways, mechanisms of chronic pain in rheumatic immune diseases, neuroimmune mechanisms in central and peripheral sensitization, and related TCM pharmacology. PI of one NSFC General Project, one NSFC Youth Project, and one Zhejiang Provincial Natural Science Foundation project. Author of more than 40 SCI papers, mainly in PAIN, Arthritis Research & Therapy, Communications Biology, Neurobiology of Disease, Molecular Neurobiology, and other leading international journals.

Chronic pain in rheumatic immune diseases Neuropharmacology of Chinese medicine Neuroelectrophysiology
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Chronic Pain in Rheumatic Immune Diseases

Dissecting the heterogeneity and regulatory networks of immune cells underlying chronic pain in rheumatic immune diseases, and neuro-immune crosstalk mechanisms.

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Neuropharmacology of Chinese Medicine

Investigating the targeted mechanisms by which traditional Chinese medicine formulas and compounds regulate chronic pain.

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Neuroelectrophysiology

Application of patch-clamp electrophysiology to the study of neuro-immune mechanisms.

2026

A Potential Central Hub of Histamine in the Microbiota–Gut–Joint Axis in Rheumatoid Arthritis: Mechanisms and Translational Implications

International Journal of Molecular Sciences  ·  27(5): 2315
Yiqing Kong; Yu Deng; Yuan Liu; Yuge Han; Yuandan Zhang; Zihan Qi; Menglei Cao; Yingying Li; Yu Du; Yan Jin; Jie Yu (Corresponding author)
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2026

Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization

Frontiers in Immunology  ·  CAS Q2 (Top)
Weidong Lai, Xin Tang ..., Jie Yu, Chengping Wen (Co-corresponding)
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2025

CRMP2 phosphorylation regulates polarization and spinal infiltration of CD4+ T lymphocytes, inhibits spinal glial activation

PAIN  ·  CAS Q1 (Top)
Yue-Peng Jiang; Jun-Jun Wen; Xiao Ma; Cun-Rui Yuan; Feng Zhou; Meng-Jia Zheng; Xin Tang; Xi-Kang Yu; Wei-Dong Lai; Yi-Han Zhou; Wen-Hua Yu; Wen-Ting You; Yan Jin; Ki Duk Park; Rajesh Khanna; Cheng-Ping Wen; Jie Yu (Corresponding author)
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2025

A glutamatergic innervation from medial area of secondary visual cortex to lateral posterior thalamic nucleus facilitates nociceptive and neuropathic pain

Communications Biology  ·  CAS Q1 (Top)
Bei Tan, Tingting Hu, ... Jie Yu, Yu Du, Zhong Chen (Co-corresponding)
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2024

Sinomenine ameliorates fibroblast-like synoviocytes dysfunction by promoting phosphorylation and nuclear translocation of CRMP2

Journal of Ethnopharmacology  ·  324: 117704  ·  CAS Q2 (Top)
Jie Yu, Song Wang, Si-Jia Chen, et al. (First author)
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PhD Candidates (Year 2) PhD Candidate (Year 1) Master's Students (Year 3) Master's Students (Year 2) Master's Students (Year 1)
Team photo
2026 Team Photo
Yu Jie

Yu Jie

Associate Researcher · PI

陈思佳

PhD Candidate · Year 2

袁存睿

PhD Candidate · Year 1

祁紫含

Master's Student · Year 3

Cao Menglei

曹梦雷

Master's Student · Year 3

周峰

Master's Student · Year 3

张芳菲

Master's Student · Year 2

张奕邦

Master's Student · Year 2

Zhang Luyao

张璐瑶

Master's Student · Year 1

Yan Luyao

闫璐瑶

Master's Student · Year 1

From Apr 2026
Admissions Our lab collaborates with Prof. Rajesh Khanna (University of Florida) and Prof. Aubin Moutal (Saint Louis University). We are recruiting 2 master's students for Fall 2026. Students interested in the mechanisms of chronic pain in rheumatic immune diseases are welcome to contact us!
May 2026
Lab News 📄 Click for details
2026 Master's Thesis Defense Held Successfully
Mar 2025
Publication Our lab published a study in PAIN on how CRMP2 regulates T-lymphocyte-induced central sensitization, attracting wide attention both at home and abroad.
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Email
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Lab Address
Binwen Campus, Building 20, Room 20209
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Postal Address
No. 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang 310058